Annotation

Detailed clinical and specimen data associated with each phase of specimen accrual are meticulously recorded at each LCBRN Resource Site and entered into a secure, central database. All samples provided to investigators are annotated with the information listed below.  De-identified pathology reports are also available for an additional fee.

 Patient History

  • Demographics – age, race, gender
  • Height and weight
  • History of prior malignancies
  • Family history of lung cancer
  • Military service, branch, year service began/ended
  • History of carcinogen exposure (i.e. chemical, asbestos)
  • Category of carcinogen exposure (military or civilian)
  • Smoking history (pack-years)
  • Prior treatment for any known lung cancer

Pre-op Surgery Data

  • ECOG performance status
  • Anatomic location of the tumor
  • Two-dimensional tumor dimensions as measured on CT scan
  • PET-CT maximal standard uptake value (SUV max)
  • Presence or not of pleural effusion
  • Presence or not of chest wall or mediastinal invasion
  • Presence or not of a ground glass appearance of the tumor

Biofluid Procurement Data/Events

  • Anesthetic status of patient at collection
  • Time fluid collected from patient
  • Time fluid received in processing lab
  • Time fluid frozen

Surgery Data/Events

  • Surgical approach
  • Surgical procedure used to remove the procured tumor
  • Overall surgical procedure
  • Type of mediastinal lymph node dissection
  • Clamp/ischemia time
  • Time specimen excised from patient

Tissue Procurement Data/Events

  • Time specimen received in surgical pathology
  • Time specimen received by procurement technician
  • Frozen specimen weight (g)
  • Time specimen frozen/fixed
  • Length of time in fixative

Post-Surgery Data

  • Final clinical/pathologic stage
  • Tumor histology
  • Tumor grade
  • Presence or not of lymphangio invasion
  • Pre-operative treatment effect
  • Presence or not of residual tumor

Follow-up Data

  • Adjuvant therapies
  • Evidence of recurrence at follow-up intervals
  • Subsequent treatment post recurrence
  • Post-procedure mortality and reason for death

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