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Lung Cancer Biospecimen Resource Network

Welcome to the Lung Cancer Biospecimen Resource Network (LCBRN). The LCBRN obtains tissue and biofluid samples from lung cancer patients for use in biomedical research. Subjects voluntarily donate tissue, bronchial lavage fluid, blood, urine and saliva, and have all signed informed consent documents allowing the use of their samples in research.

The LCBRN is a network of 3 academic medical centers: Medical University of South Carolina (MUSC), The University of Virginia (UVA) and Washington University in St. Louis (WUSTL). Biospecimens are collected at these sites according to standard operating procedures and are shipped to the LCBRN Coordination Center at UVA for storage.

The LCBRN is an open access biorepository that provides specimens to academic and private industry scientists worldwide. Researchers desiring material from the LCBRN must have local approval to work with coded-linked human biospecimens, must submit an application for review by the LCBRN Scientific Review Panel, and must have institutional approval for the provisions in the LCBRN investigator agreement.

LCBRN MISSION STATEMENT: The LCBRN will collect, annotate, store, and distribute human lung cancer biospecimens in a manner that embraces the highest ethical standards for human subjects research, that conforms to the best practices of biorepository science, and that furthers basic, translational and clinical research in the understanding, diagnosis and treatment of this disease.

Since May 2011, the LCBRN has enrolled 763 patients, 78% of whom have contributed both lung tumor and baseline fluids. Follow-up specimens and/or clinical data are collected every 6 months post baseline fluid collection for up to 5 years. Biospecimens are also available from a select few 48 patients who were presumed to have lung cancer but were found to have benign disease. Stats updated 10/02/2014

As of 08/01/2014, the LCBRN is no longer enrolling new subjects or collecting follow-up biospecimens. Clinical follow-up data, however, will continue to be collected on all currently enrolled patients until 09/01/2017.

LCBRN Flow Chart