Annotation

Detailed clinical and specimen data associated with each phase of specimen accrual are meticulously recorded at each LCBRN Resource Site and entered into a secure, central database. All samples provided to investigators are annotated with the information listed below.  De-identified pathology reports are also available for an additional fee.

 

PATIENT HISTORY

  • Demographics – age, race, gender

  • Height and weight History of prior malignancies

  • Family history of lung cancer

  • Military service, branch, year service began/ended

  • History of carcinogen exposure (i.e. chemical, asbestos)

  • Category of carcinogen exposure (military or civilian)

  • Smoking history (pack-years)

  • Prior treatment for any known lung cancer

PRE-OP SURGERY DATA
  • ECOG performance status
  • Anatomic location of the tumor
  • Two-dimensional tumor dimensions as measured on CT scan
  • PET-CT maximal standard uptake value (SUV max)
  • Presence or not of pleural effusion
  • Presence or not of chest wall or mediastinal invasion
  • Presence or not of a ground glass appearance of the tumor
BIOFLUID PROCUREMENT DATA/EVENTS

  • Anesthetic status of patient at collection

  • Time fluid collected from patient

  • Time fluid received in processing lab

  • Time fluid frozen

SURGERY DATA/EVENTS

  • Surgical approach
  • Surgical procedure used to remove the procured tumor
  • Overall surgical procedure
  • Type of mediastinal lymph node dissection
  • Clamp/ischemia time
  • Time specimen excised from patient
TISSUE PROCUREMENT DATA/EVENTS

  • Time specimen received in surgical pathology

  • Time specimen received by procurement technician

  • Frozen specimen weight (g)

  • Time specimen frozen/fixed Length of time in fixative

POST-SURGERY DATA
  • Final clinical/pathologic stage
  • Tumor histology
  • Tumor grade
  • Presence or not of lymphangio invasion
  • Pre-operative treatment effect
  • Presence or not of residual tumor
FOLLOW-UP DATA

  • Adjuvant therapies

  • Evidence of recurrence at follow-up intervals

  • Subsequent treatment post recurrence

  • Post-procedure mortality and reason for death